Rise-uP is a medical care initiative aimed at improving the treatment of patients suffering from acute, subacute, and recurrent nonspecific low back pain. It incorporates digital health tools such as the TherapieNavigator, an electronic case report form that complies with German guidelines, allowing healthcare professionals to access patient data and provide guided treatment. The initiative also includes teleconsultation, enabling collaboration between general practitioners and pain specialists to effectively manage high-risk patients through secure video conferencing. Additionally, participants can utilize the Kaia App, which provides free access to a personalized multimodal pain therapy program, featuring physical exercises, educational materials, and mindfulness techniques tailored to individual patient needs through an algorithmic approach. The health focus areas of Rise-uP include injuries, mental health, health promotion, and other related aspects.