MSFeCARE significantly elevates pediatric primary healthcare quality in low-resource settings through its advanced electronic Decision Support System (eDSS), MSFeCARE-Ped. Incorporating digitalized Integrated Management of Childhood Illness (IMCI) guidelines, the system provides comprehensive guidance for frontline clinicians, enhancing diagnostic accuracy and treatment efficacy. Since its inception in 2017, MSFeCARE has been implemented in 16 MSF projects across 39 healthcare facilities, facilitating over 410,000 consultations in countries such as the Central African Republic, Democratic Republic of Congo, Kenya, Mali, Mozambique, Niger, and South Sudan, with past projects in Chad, Nigeria, and Tanzania. This broad implementation underscores its effectiveness in improving clinical outcomes and rationalizing antibiotic prescriptions, thereby reinforcing healthcare systems' trustworthiness and efficiency. The primary objective of MSFeCARE is to improve the quality of care for patients and foster the autonomy of frontline healthcare workers through guided decision-making, evidence-based diagnostics and prescriptions, enhanced learning processes, and clinical supervision. Targeting children under 5 years old, the project operates under the aegis of Doctors Without Borders. The project began on June 1, 2014, and concluded on June 1, 2023, in Switzerland, functioning as a pilot project with trials focusing on the integrated management of newborn and childhood infections (IMNCI). The initiative uses the MSFeCARE module for children aged 2 months to 5 years, supported by decision support software. Funded by Doctors Without Borders and backed by quantitative evidence, the project has benefited over 100,000 individuals. For more detailed information, the project's progress and research findings can be accessed through the MSF Transformation website and relevant publications.