Developed by a consortium led by HR Wallingford and sponsored by the United Kingdom (UK) Space Agency’s International Partnership Programme, D-MOSS is the first fully integrated dengue fever forecasting system incorporating Earth observations and seasonal climate forecasts to issue warnings on a routine basis. D-MOSS integrates multiple stressors such as water availability, land-cover, precipitation, and temperature with data on past dengue fever incidents. This information is used to develop statistical models of disease incidence, which can then be used to forecast dengue outbreaks based on seasonal weather and hydrological forecasts as well as other factors. D-MOSS takes the form of a web-based platform. The system’s architecture is based on open and non-proprietary software, where possible, and on flexible deployment into platforms including cloud-based virtual storage and application processing. This suite of innovative tools will allow beneficiaries to issue alerts for dengue fever up to eight months in advance (with a view to develop the same for Zika virus) and provide assessments of vector-borne disease risk under future climate and land use change scenarios. It will allow local communities to mobilize and eliminate mosquito-breeding sites, thus reducing dengue incidence.