The Digital Health and Rights Project (DHRP) was launched in 2019 in response to the rapid growth of new partnerships by global and national health agencies with big tech companies, to gather empirical evidence of the effects of the digital transformation on young adults living with HIV and young key populations in low- and middle-income countries, and use this evidence to inform national and global health governance. Working together, Sara (Meg) Davis (then Geneva Graduate Institute, now University of Warwick), Allan Maleche (KELIN), Mike Podmore (STOPAIDS), and leaders of the Global Network of People living with HIV (GNP+) launched a new partnership that uses participatory action research to build knowledge and expertise in national and global civil society networks. The consortium investigates how digital technologies, health, and human rights intersect in a context of global and local inequalities, and advocates collectively for rights of young adults and civil society in low- and middle-income countries. Building on learning and mobilization in the global HIV response, DHRP explores barriers to digital access, threats faced by marginalized groups online, and the transformative power of community-led networks for research, education and action from local to global levels. The project focuses on the intersection of digital technologies, health, and human rights amid global inequalities, advocating for the rights of young adults and civil society. DHRP highlights barriers to digital access and the threats marginalized groups face online, emphasizing the potential of community-led networks for research and action. It conducts participatory research involving diverse young adults to generate evidence that informs the future of human rights in the digital age.