GxAlert is an open-source digital platform that enhances country-level surveillance for tuberculosis (TB) by enabling seamless data flow within health systems. It features a versatile data management system compatible with various internet-connected diagnostic devices, such as electronic tuberculosis managers and monitoring and evaluation (M&E) systems. Additionally, GxAlert can deliver targeted SMS alerts to facility managers, health officers, and suppliers upon TB detection. The platform efficiently gathers and transmits electronic diagnostic and operational data directly from diagnostic instruments, with a primary focus on communicable diseases.